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KMID : 1151820190130020253
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Journal of the Korean Society of Radiology
2019 Volume.13 No. 2 p.253 ~ p.260
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Analysis of Radiation Dose Enhancement for Spread Out Bragg-peak of Proton
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Hwang Chul-Hwan
Kim Jung-Hoon
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Abstract
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Radiation dose enhancement is a method of increasing the cross section of interaction, thus increasing the deposited dose. This can contribute to linear energy transfer, LET and relative biological effectiveness, RBE. Previous studies on dose enhancement have been mainly focused on X, γ-rays, but in this study, the dose enhancement was analyzed for proton using Monte Carlo simulation using MCNP6. Based on the mathematical modeling method, energy spectrum and relative intensity of spread out Bragg-peak were calculated, and evaluated dose enhancement factor and dose distribution of dose enhancement material, such as aurum and gadolinium. Dose enhancement factor of 1.085-1.120 folds in aurum, 1.047-1.091 folds in gadolinium was shown. In addition, it showed a decrease of 95% modulation range and practical range. This may lead to an uncertain dose in the tumor tissue as well as dose enhancement. Therefore, it is necessary to make appropriate corrections for spread out Bragg-peak and practical range from mass stopping power. It is expected that Monte Carlo simulation for dose enhancement will be used as basic data for in-vivo and in-vitro experiments.
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KEYWORD
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Radiation Dose Enhancement, Monte Carlo simulation, Spread Out Bragg-peak
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